CAS number：1260181-14-3 molecular formula：C27H25F3N4O4
TCS 21311 (NIBR3049) 是一种有效的高选择性 JAK3 抑制剂，其 IC50 为 8 nM，它的选择性是 JAK1，JAK2 和 TYK2 的100倍以上。TCS 21311 (NIBR3049) 抑制 PKCα，PKCθ 和 GSK3β，IC50 值分别为 13、68 和 3 nM。 TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively.
| Chinese alias | 3-[5-[4-(2-羟基-2-甲基-1-氧丙基)-1-哌嗪基] -2-(三氟甲基)苯基] -4-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮 | ||
| English alias | NIBR3049 | NIBR-3049 | J-005320 | 3-[5-[4-(2-hydroxy-2-methylpropanoyl)piperazin-1-yl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione | FT-0674827 | 1260181-14-3 | JAK3/GSK-3beta/PKCalpha Inhibitor - CAS 1260181-14-3 | CLGRAWDGLMENOD-UHFFFA | ||
| CAS number | 1260181-14-3 | molecular formula | C27H25F3N4O4 |
| molecular weight | 526.51 g/mol | Exact mass | - |
| PSA | 106.000 Ų | logp | 2.900 |
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