compound introduction
SA57 是一种有效的选择性 FAAH 抑制剂，对小鼠和人类 FAAH 的 IC50 分别为 3.2 nM 和 1.9 nM。SA57 还抑制 2-花生四烯酸甘油水解酶 MAGL (对小鼠和人类 MAGL 的 IC50 分别为 410 nM 和 1.4 μM）和小鼠 α/β-水解酶结构域蛋白 6 (mABHD6; IC50 为 850 nM)，但不抑制其他脑丝氨酸水解酶。
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SA 57
CAS number：1346169-63-8 molecular formula：C17H23ClN2O3
overview
Specs
| Chinese alias | - | ||
| English alias | 4-[2-(4-Chlorophenyl)ethyl]-1-piperidinecarboxylic acid 2-(methylamino)-2-oxoethyl ester | (Z)-2-((4-(4-chlorophenethyl)piperidine-1-carbonyl)oxy)-N-methylacetimidic acid | ||
| CAS number | 1346169-63-8 | molecular formula | C17H23ClN2O3 |
| molecular weight | 338.83 g/mol | Exact mass | - |
| PSA | 58.600 Ų | logp | 3.300 |
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