CAS number：956906-93-7 molecular formula：C20H20N8O4S
PF-04217903 mesylate 是一种高效的ATP竞争性 c-Met 激酶抑制剂，Ki 为 4.8 nM。PF-04217903 mesylate 相对于 208 个激酶显示出 1000 倍以上的选择性。具有抗血管生成特性。 PF-04217903 methanesulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met). Application： PF-04217903 has been used as tyrosine-protein kinase Met (C-Met) selective inhibitor in Madin-Darby Canine kidney (MDCK) cells[1] and NT2D1 non-seminoma cells.
| Chinese alias | 4-[1-(6-喹啉基甲基)-1H-1,2,3-三唑并[4,5-b]吡嗪-6-基] -1H-吡唑-1-乙醇甲磺酸酯 | ||
| English alias | 2-(4-{1-[(quinolin-6-yl)methyl]-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl}-1H-pyrazol-1-yl)ethan-1-ol; methanesulfonic acid | PF-04217903 methanesulfonate | methanesulfonic acid;2-[4-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]pyrazol-1-yl]ethanol | P | ||
| CAS number | 956906-93-7 | molecular formula | C20H20N8O4S |
| molecular weight | 468.49 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 170.000 Ų | logp | - |
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