CAS number：1217474-40-2 molecular formula：C19H26N2O4•2CH3SO3H
NAS181 是一种有效和选择性的大鼠 5-HT1B 受体拮抗剂，Ki 值为 47 nM。NAS181 对 r5-HT1B 的选择性比牛 5-HT1B 受体 (Ki=630 nM) 高 13 倍。NAS181 通过抑制末端 r5-HT1B 自身受体来增加 5-HT 转换和 5-HT 的突触浓度。 NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors.
| Chinese alias | (2R)-2-[[[[[3-(4-吗啉基甲基)-2H-1-苯并吡喃-8-基]氧基]甲基]吗啉二甲磺酸酯 | ||
| English alias | SR-01000597970 | NAS-181 dimesylate | (2R)-2-[[[3-(4-Morpholinylmethyl)-2H-1-benzopyran-8-yl]oxy]methyl]morpholine dimethanesulfonate | 1217474-40-2 | NAS-181 (dimesylate) | MS-29936 | SR-01000597970-1 | HY-103156 | methanesulfonic acid;(2R)-2-[[3-(morpho | ||
| CAS number | 1217474-40-2 | molecular formula | C19H26N2O4•2CH3SO3H |
| molecular weight | 538.63 g/mol | Exact mass | ≥97% |
| PSA | 178.000 Ų | logp | - |
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