CAS number：1883548-84-2 molecular formula：C34H28N4O2•HCl
AMG PERK 44 是一种口服有效的，高选择性的 PERK 抑制剂，IC50 为 6 nM。AMG PERK 44 对 PERK 的选择性分别是 GCN2 (IC50=7300 nM) 和 B-Raf (IC50 >1000 nM) 的 1000 倍和 160 倍。AMG PERK 44 可以诱导自噬 (autophagy)。 AMG PERK 44 is an orally effective, highly selective PERK inhibitor with an IC50 of 6 nM. The selectivity of AMG PERK 44 for PERK is 1000 and 160 times higher than that of GCN2 (IC50=7300 nM) and B-Raf (IC50>1000 nM), respectively. AMG PERK 44 can induce autophagy.
| Chinese alias | 4-[2-氨基-4-甲基-3-(2-甲基-6-喹啉基)苯甲酰基] -1,2-二氢-1-甲基-2,5-二苯基-3H-吡唑-3-盐酸盐 | ||
| English alias | 4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride | ||
| CAS number | 1883548-84-2 | molecular formula | C34H28N4O2•HCl |
| molecular weight | 561.07 g/mol | Exact mass | ≥95% |
| PSA | - | logp | - |
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