Fluxametamide

Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels , with IC 50 of 1.95 nM and 225 nM for M. domestica GABACls and GluCls. In Vitro Fluxametamide is an antagonist of GABA- and glutamate-gated chloride channels, dose-dependently inhibits currents induced by GABA and glutamate in M. domestica GABACls and GluCls, with IC 50 values of 1.95 (1.18-3.21) nM and 225 (137-372) nM, respectively, and displays potent antagonistic activity against T. urticae GABACls with an IC 50 of 0.219 (0.127-0.381) nM. Fluxametamide inhibits GABA responses in the wild-type L. striatellus GABACls with IC 50 values of 1.40 (0.57-3.29) nM; in the A2′N mutant GABACls, the IC 50 value is 3.51 (2.17-5.69) nM. Moreover, Fluxametamide scarcely inhibits GABA (EC 50 )-induced currents in rat GABACls at 10 μM and with no inhibition on glycine (EC 50 )-induced current in human α1 GlyCls at tested concentrations. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Fluxametamide shows significant insecticidal activity with an LD 50 (LD 95 ) value of 12.9 ± 4.9 ng/fly (38.7 ± 6.3 ng/fly) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 1.95 nM ( M. domestica GABACls), 225 nM ( M. domestica GluCls)

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