WEE1-IN-5 is a potent WEE1 inhibitor with an IC 50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer In Vitro WEE1-IN-5 exhibits an EC 50 of 188 nM in pCDC2 and an IC 50 shift for CYP3A4/5. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo WEE1-IN-5 (5mg/kg for PO; 1 mg/kg for IV; single dosage) exhibits a CL of 14 mL/min/kg, an AUC int 1324 h·ng/mL and bioavailability of 35% in SD rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC 50 : 0.8 nM (WEE1), 188 nM (CDC2)
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WEE1-IN-5
CAS number：2243882-74-6 molecular formula：C26H28Cl2N6O
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2243882-74-6 | molecular formula | C26H28Cl2N6O |
| molecular weight | 511.45 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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