(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent α1-adrenoceptor antagonist with K i values of 6.51 nM, 1.01 nM and 1.97 nM for α1a , α1b and α1d-adrenoceptor , respectively In Vitro (R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor with K i values of 3.85 μM, 0.33 μM and 0.37 μM, respectively. (R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues. Because it is a weaker antagonist at α2B sites than its enantiomer, it may be possible to use (R)-Terazosin to differentiate between pharmacological effects mediated by subtypes of α2-adrenoceptors in animal studies. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo (R)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC 30 of 5.69. (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA 2 values of 7.5 and 5.31, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 6.51 nM (α1a-adrenoceptor), 1.01 nM (α1b-adrenoceptor) and 1.97 nM (α1d-adrenoceptor)
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(R)-Terazosin
CAS number：109351-34-0 molecular formula：C19H25N5O4
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| Chinese alias | (R)-特拉唑嗪 | ||
| English alias | - | ||
| CAS number | 109351-34-0 | molecular formula | C19H25N5O4 |
| molecular weight | 387.43 g/mol | Exact mass | ≥99% |
| PSA | 103.000 Ų | logp | 1.400 |
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