Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor. In Vitro Vaborbactam is a broad spectrum of inhibition of β-lactamases, with particularly potent activity against KPC, CTX-M, SHV, and CMY enzymes. Vaborbactam restores SM 7338 activity for 72.7 to 98.1% of CPE isolates at ≤2 μg/mL, and maximum potentiation is achieved with fixed concentrations of ≥8 μg/mL of the inhibitor (≥96.5% of isolates are inhibited at ≤2 μg/mL of SM 7338-vaborbactam). SM 7338-vaborbactam with a fixed concentration of 8 μg/mL of the inhibitor (MIC50, ≤0.06 μg/mL for all organisms) inhibits 93.7% of the CPE isolates displaying elevated SM 7338 MICs at ≤1 μg/mL. By forming a reversible dative bond with the blactamase, vaborbactam acts as a competitive inhibitor and is not hydrolyzed by the b-lactamase. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Vaborbactam is well tolerated and has a half-life of 1.23 h, and steadystate volume of distribution of 21.0 L in subjects. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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Vaborbactam
CAS number：1360457-46-0(Water) molecular formula：C12H16BNO5S
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| Chinese alias | 伐利巴坦 | ||
| English alias | - | ||
| CAS number | 1360457-46-0(Water) | molecular formula | C12H16BNO5S |
| molecular weight | 297.14 g/mol | Exact mass | - |
| PSA | - | logp | - |
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