RIPK1 inhibitor 22b是一种选择性有效的 RIPK1 抑制剂，Kd 值为 4 nM，IC50值为 11 nM。在实验性 B16 黑色素瘤肺转移模型中表现出优异的抗转移活性。 体外活性 在TSZ诱导的HT29细胞坏死模型中，RIPK1 inhibitor 22b 显示出强大的细胞保护效果（EC50为2nM）。RIPK1 inhibitor 22b 对多个其他激酶（Flt4、TrkA、TrkB、TrkC、Axl、HRI、Mer和MAP4K5）也表现出显著活性，其IC50分别为20、26、8、7、35、26、29和27nM。 RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a K d of 4 nM and an enzymatic IC 50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model In Vitro RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC 50 of 2nM. RIPK1-IN-7 displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC 50 s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 11 nM (RIPK1), Kd: 4 nM (RIPK1)
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RIPK1-IN-7
CAS number：2300982-44-7(DMSO) molecular formula：C25H22F3N5O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2300982-44-7(DMSO) | molecular formula | C25H22F3N5O2 |
| molecular weight | 481.5 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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