SC 51089 free base

SC 51089 free base is a selective antagonist of prostaglandin E 2 EP1 receptor , with K i s of 1.3, 11.2, 17.5, and 61.1 μM for EP1 , TP , EP3 , and FP receptors , respectively. SC 51089 free base exhibits neuroprotective activity In Vitro SC 51089 free base (5 μM; 24 h) attenuates prostaglandin E2 (PGE2)-induced the death of neuronal cells exposed to t-BuOOH. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SC 51089 free base (40 μg/kg; infused i.p. for 28 d) ameliorates motor coordination and balance dysfunction and rescues long-term memory deficit in R6/1 mouse model of HD. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: R6/1 mouse model of Huntington's disease (HD), from 13 to 18 weeks of ageDosage: 40 μg/kg/day Administration: Infused i.p. at a rate of 0.11 μL/h during 28 days by osmotic mini-pump system Result: Ameliorated motor coordination and balance dysfunction. Rescued long-term memory deficit. Improved the expression of specific synaptic markers. Reduced the number of huntingtin nuclear inclusions in the striatum and hippocampus. Form:Solid IC50& Target:EP1 1.3 μM (Ki) TP 11.2 μM (Ki) EP3 17.5 μM (Ki) FP 61.1 μM (Ki)

No numbering system information yet

No physical and chemical property information yet

No safety information yet

No production method and use information yet

No upstream information yet

No downstream information yet

No related product information yet