RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f , with a K d of 2.8 μM In Vitro RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples. RB-3 inhibits H2A ubiquitination with an IC 50 of 1.6 μM. RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes. RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: TEX cells. Concentration: 6, 12, 25 μM. Incubation Time: 8d. Result: Dose-dependently increased C/EBPα-p42 protein levels. Form:Solid IC50& Target:Kd: 2.8 μM (RING1B-BMI1f)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
RB-3
CAS number：2396639-11-3 molecular formula：C24H20ClN3O2
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2396639-11-3 | molecular formula | C24H20ClN3O2 |
| molecular weight | 417.89 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
