CAS number：1933528-96-1 molecular formula：C22H23ClFN3O2S
MDR-652是瞬时受体电位香草酸亚型 1 的选择性激动剂，对 hTRPV1 和 rTRPV1 的Ki 分别为 11.4 和 23.8 nM，EC50分别为 5.05 和 93 nM。MDR-652在缓解疼痛方面有研究的价值。 Information MDR-652 MDR-652 is a potent and specific agonist of transient receptor potential vanilloid 1 (TRPV1) with Ki of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1, respectively. MDR-652 has excellent and dose-dependent analgesic activity. Targets hTRPV1 (Cell-free assay); rTRPV1 (Cell-free assay) 11.4 nM(Ki); 23.8 nM(Ki)
| Chinese alias | - | ||
| English alias | N-[[4-(3-chlorophenyl)-2-(1,1-dimethylethyl)-5-thiazolyl]methyl]-N'-[3-fluoro-4-(hydroxymethyl)phenyl]-urea | ||
| CAS number | 1933528-96-1 | molecular formula | C22H23ClFN3O2S |
| molecular weight | 447.95 g/mol | Exact mass | ≥97% |
| PSA | 102.000 Ų | logp | 4.700 |
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