compound introduction
Dooku1 是Yoda1 的一个类似物，是选择性的、内源性的 Piezo1通道的拮抗剂，在HEK 293 细胞以及HUVEC 中测得对2 μM Yoda1 诱导的钙离子流的IC50 值分别为1.3 μM 和1.5 μM。Dooku1 抑制Yoda1 诱导的主动脉舒张。
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Dooku 1
CAS number：2253744-54-4 molecular formula：C13H9Cl2N3OS
overview
Specs
| Chinese alias | 2-[((2,6-二氯苄基)硫基)-5-(1H-吡咯-2-基)-1,3,4-恶二唑 | 杜库 1 | ||
| English alias | 2-[(2,6-Dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole | Dooku1 | 2-((2,6-dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazol | ||
| CAS number | 2253744-54-4 | molecular formula | C13H9Cl2N3OS |
| molecular weight | 326.2 g/mol | Exact mass | - |
| PSA | 80.000 Ų | logp | 3.800 |
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