compound introduction
JNJ-303 是一种特殊的延迟整流 Kv 阻滞剂。JNJ 303 可以有效阻断 IKs，IC50 值为 64 nM。JNJ-303 可用于糖尿病、肥胖症和中枢神经系统的研究。 应用： JNJ 303 是有效的IKs阻断剂，IC50为 64 nM。它浓度在 3.3 μM 时对其他心脏通道无任何影响。它诱导 QT 延长并引起无端尖端扭转型室性心动过速。
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JNJ 303
CAS number：878489-28-2 molecular formula：C21H29ClN2O4S
overview
Specs
| Chinese alias | 2-(4-氯苯氧基)-2-甲基-N-[5-[(甲基磺酰基)氨基]三环[3.3.1.13,7]癸-2-基]-丙酰胺 | ||
| English alias | 878489-28-2 | JNJ 303 | rel-2-(4-Chlorophenoxy)-2-methyl-N-((1S,2R)-5-(methylsulfonamido)adamantan-2-yl)propanamide | 2-(4-Chlorophenoxy)-N-[(1S,3R)-5-(methanesulfonamido)-2-adamantyl]-2-methylpropanamide | DTXSID10468834 | AKOS037649271 | BS-17730 | D812 | ||
| CAS number | 878489-28-2 | molecular formula | C21H29ClN2O4S |
| molecular weight | 440.98 g/mol | Exact mass | - |
| PSA | 92.900 Ų | logp | 3.400 |
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