CAS number：857876-30-3 molecular formula：C22H23N5O·2H3PO4
Motesanib Diphosphate (AMG-706)是一种有效的ATP竞争性的VEGFR1/2/3抑制剂，IC50分别为2 nM/3 nM/6 nM；对Kit具有相似的抑制活性，对VEGFR选择性比PDGFR和Ret高10倍。An ATP-competitive inhibitor. Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit, ~10-fold more selective for VEGFR than PDGFR and Ret. An ATP-competitive inhibitor.
| Chinese alias | 二磷酸莫替沙尼 | ||
| English alias | AMG 706 | CCG-264783 | Motesanib (Diphosphate) | MOTESANIB PHOSPHATE [JAN] | N-(3,3-Dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide diphosphate | trans-3-(5-methyl-2-furyl)acrolein | Motesanib diphosphate | N-(3,3-dimethy | ||
| CAS number | 857876-30-3 | molecular formula | C22H23N5O·2H3PO4 |
| molecular weight | 569.44 g/mol | Exact mass | ≥98% |
| PSA | 234.000 Ų | logp | - |
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