CAS number：939791-38-5 molecular formula：C21H20F3N7O3S·C6H6O3S
PF-00562271是PF-562271的苯磺酸盐，是一种有效的，ATP竞争性，可逆的FAK抑制剂，IC50为1.5 nM，作用于Pyk2比作用于FAK效果低10倍左右，比作用于其他蛋白激酶（除了一些CDKs）选择性高100倍以上。 PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. A potent inhibitor of focal adhesion kinase (FAK) and Pyk2.
| Chinese alias | PF 562271 苯磺酸盐 | ||
| English alias | AC-27465 | AM20090125 | SCHEMBL20471937 | GTPL7332 | METHANESULFONAMIDE, N-(3-(((2-((2,3-DIHYDRO-2-OXO-1H-INDOL-5-YL)AMINO)-5-(TRIFLUOROMETHYL)-4-PYRIMIDINYL)AMINO)METHYL)-2-PYRIDINYL)-N-METHYL-, BENZENESULFONATE | PF-562271 benzenesulfonate | N-methyl-N- | ||
| CAS number | 939791-38-5 | molecular formula | C21H20F3N7O3S·C6H6O3S |
| molecular weight | 665.66 g/mol | Exact mass | 10mM in DMSO |
| PSA | 200.000 Ų | logp | - |
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