CAS number：211555-08-7 molecular formula：C16H15N3O3
在WHI-P180中，盐酸盐是lgE介导的肥大细胞对体内和体外变应原反应的有效抑制剂。盐酸盐WHI-P180还可以通过阻断ATP位点来抑制细胞周期蛋白依赖性激酶2（Cdk2; IC | 50 | = 1μM）。 WHI-P180, Hydrochloride is a potent inhibitor of lgE-mediated mast cell responses to allergens|in vitro|and|in vivo|. WHI-P180, Hydrochloride also inhibits cyclin-dependent kinase 2 (Cdk2; IC|50|= 1 μM) by blocking the ATP site.
| Chinese alias | - | ||
| English alias | DB03365 | AKOS002350928 | BDBM4622 | WHI-P180(Janex 3) | DTXSID50943478 | s6520 | Phenol, 3-[(6,7-dimethoxy-4-quinazolinyl)amino]- | WHI-P180; 4-(3'-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, HCl | AS-35327 | WHI-P180, Hydrochloride | 1di8 | 3-[(6,7-di | ||
| CAS number | 211555-08-7 | molecular formula | C16H15N3O3 |
| molecular weight | 297.31 | Exact mass | ≥98% |
| PSA | 76.5 | logp | 3 |
| CAS | 211555-08-7 |
| Wikidata | Q27094307 |
| ChEMBL ID | CHEMBL127907 |
| AIDS 编号 | 503017 |
| DrugBank ID | DB03365 |
| PubChem CID | 5687 |
| Nikkaji Number | J1.074.540C |
| Pharos Ligand ID | 79FD916DJKFK |
| DSSTox Substance ID | DTXSID50943478 |
| Metabolomics Workbench ID | 147889 |
| PubChem Reference Collection SID | 505509001 |
| XLogP3 | XLogP3-AA: 3 |
| 复杂性 | 358 |
| Exact Mass | 297.11134135 |
| 形式电荷 | 0 |
| 重原子计数 | 22 |
| Molecular Weight | 297.31 |
| Monoisotopic Mass | 297.11134135 |
| 可旋转键计数 | 4 |
| 氢键供体计数 | 2 |
| 氢键受体计数 | 6 |
| 共价键单元计数 | 1 |
| 同位素原子计数 | 0 |
| 拓扑极性表面积 | 76.5 Ų |
| 定义键立体中心计数 | 0 |
| 定义原子立体中心计数 | 0 |
| 未定义键立体中心计数 | 0 |
| 未定义原子手性中心计数 | 0 |
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