compound introduction
cFMS受体抑制剂IV是一种可渗透细胞的呋喃羧酰胺化合物，可作为有效，可逆且具有ATP竞争性的c-Fms-CSF-1R（cFMS / CSF-1R）抑制剂。cFMS受体抑制剂IV在无细胞试验和CSF-1 / M-CSF刺激的HEK-293细胞中阻断cFMS自磷酸化。 cFMS Receptor Inhibitor IV is a cell-permeable furan carboxamide compound that acts as a potent, reversible, and ATP-competitive c-Fms-CSF-1R (cFMS/CSF-1R) inhibitor. cFMS Receptor Inhibitor IV blocks cFMS autophosphorylation in cell-free|in vitro|kinase assays and in CSF-1/M-CSF-stimulated HEK-293 cells. A cell-permeable furan carboxamide compound that acts as a potent, reversible, and ATP-competitive cFMS/CSF-1R inhibitor that blocks cFMS autophosphorylation both in CSF-1/M-CSF-stimulated HEK-293 cells (IC50 = 76 nM) and in cell-free in vitro kinase assays (IC50 = 17 nM).
