compound introduction
Information JCN037 (JGK037) is potent, non-covalent and brain-penetrant inhibitor of EGFR tyrosine kinase with IC50 of 2.49 nM, 3.95 nM, 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively.
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JCN037
CAS number：2305154-31-6 molecular formula：C16H11BrFN3O2
overview
Specs
| Chinese alias | - | ||
| English alias | JGK037 | N-(3-Bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine | ||
| CAS number | 2305154-31-6 | molecular formula | C16H11BrFN3O2 |
| molecular weight | 376.18 g/mol | Exact mass | ≥98% |
| PSA | 56.300 Ų | logp | 3.900 |
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