CAS number：2260886-64-2 molecular formula：C33H41ClN8O2
JND3229 是一种可逆性的 EGFR C797S 抑制剂，对 EGFR L858R/T790M/C797S 、EGFR WT 和 EGFR L858R/T790M 的 IC50 值分别为 5.8、6.8 和 30.5 nM。JND3229 具有较好的抗增殖活性，能有效地抑制体内肿瘤的生长。JND3229 可用于癌症，尤其是非小细胞癌的研究。 JND3229 JND3229 is a potent reversible inhibitor of EGFR C797S with an IC50 value of 5.8 nM. JND3229 also potently suppresses EGFR L858R/T790M and EGFR WT with IC50 values of 30.5 nM and 6.8 nM, respectively.
| Chinese alias | - | ||
| English alias | N-(trans-4-(3-(2-Chlorophenyl)-7-((3-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)cyclohexyl)propionamide | ||
| CAS number | 2260886-64-2 | molecular formula | C33H41ClN8O2 |
| molecular weight | 617.18 g/mol | Exact mass | - |
| PSA | 96.900 Ų | logp | 5.000 |
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