GNE-9822

GNE-9822 is a potent, orally active and selective ITK inhibitor with a K i value of 0.7 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma. In Vitro GNE-9822 (compound 28) inhibits the phosphorylation of PLCγ with an IC 50 value of 55 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo GNE-9822 (compound 28; po and iv; 1 and 5 mg/kg) has good bioavailability and halflives observed in mouse and rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: BALB/c mouse and Sprague-Dawley rats Dosage: 1 and 5 mg/kg Administration: po (5 mg/kg) and iv (1 mg/kg) Result: 1.19 species route dose volume (mL/kg) dose (mg/kg) C max (μM) AUC (μM·h) Cl (mL/min/kg) T 1/2 (h) V ss (L/kg) %F mouse (BALB/c) IV 1.0 1.0 1.5 40 2.9 10 mouse (BALB/c) PO 5.0 50 3.8 2.7 36 Animal Model: BALB/c mouse and Sprague-Dawley rats Dosage: 1 and 5 mg/kg Administration: po (5 mg/kg) and iv (1 mg/kg) Result: 1.19 species route dose volume (mL/kg) dose (mg/kg) C max (μM) AUC (μM·h) Cl (mL/min/kg) T 1/2 (h) V ss (L/kg) %F rat (Sprague-Dawley IV 1.0 1.0 0.6 70 3.0 14 rat (Sprague-Dawley PO 2.0 5.0 0.2 1.1 40 Form:Solid

No numbering system information yet

No physical and chemical property information yet

No safety information yet

No production method and use information yet

No upstream information yet

No downstream information yet

No related product information yet