Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) 是一种新型 FAK 抑制剂,抑制 FAK 在 Tyr397 位点磷酸化,这种作用具有时间和剂量依赖性。 Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.
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Defactinib hydrochloride
CAS number:1073160-26-5 molecular formula:C20H22ClF3N8O3S
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| Chinese alias | 盐酸德法替尼 | 地法替尼盐酸盐 | ||
| English alias | N-Methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide hydrochloride | PF 04554878 hydrochloride | VS-6063 HYDROCHLORIDE | ||
| CAS number | 1073160-26-5 | molecular formula | C20H22ClF3N8O3S |
| molecular weight | 546.95 g/mol | Exact mass | - |
| PSA | 150.000 Ų | logp | - |
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