Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε , VEGFR2, MAP4K5, MNK1 , MUSK, TOPK , and TNIK (IC 50 =1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC 50 =3.46-5.27 μM for PI3K α/β/γ/K/δ). In Vitro Orobol binds to CK1ε in an ATP-competitive manner and exerts anti-obesity effects by targeting casein kinase 1 epsilon. Orobol (5-20 μM) effectively suppresses MDI (isobutylmethylxanthine, dexamethasone and insulin (MDI))-induced phosphorylation of 4E-BP1. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Orobol attenuates high fat diet-induced weight gain and lipid accumulation without affecting food intake in C57BL/6J mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: HFD-induced obesity in C57BL/6J miceDosage: 10 mg/kg Administration: Intragastrically; daily for 23 weeks Result: Significantly reduced body weight by 17.3% compared to the HFD group. Form:Solid
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Orobol
CAS number：480-23-9 molecular formula：C15H10O6
overview
compound introduction
Specs
| Chinese alias | 奥罗博尔 | ||
| English alias | Q7103718 | 3'-hydroxygenistein | 3'-hydroxy-genistein | 3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one | 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(3,4-dihydroxyphenyl)- | UNII-LU8UZM1T51 | LMPK12050251 | BRN 0292790 | Isoluteolin | NSC 678114 | SCHEMBL | ||
| CAS number | 480-23-9 | molecular formula | C15H10O6 |
| molecular weight | 286.24 g/mol | Exact mass | ≥99% |
| PSA | 107.000 Ų | logp | 2.300 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
