CAS number：2092925-89-6 molecular formula：C28H36FN3O
Palazestrant (OP-1250) 是一种抗雌激素和抗肿瘤试剂。Palazestrant 完全抑制 17b-estradiol (E2) 的活性，IC50 值为 6.4 nM，抑制 MCF7 和 CAMA-1 细胞增殖的 IC50 值为 1.4-1.6 nM。 Palazestrant 可抑制 ER+/HER2+ 癌症。 Palazestrant is an antiestrogen and antineoplastic agent. Palazestrant can completely inhibit the activity of 17b-estradiol (E2) with IC50 value of 6.4 nM, and inhibit the proliferation of MCF7 and CAMA-1 cells with IC50 value of 1.4-1.6 nM. Palazestrant can inhibit ER+/HER2+ cancer
| Chinese alias | (1R,3R)-2-(2-氟-2-甲基丙基)-3-甲基-1-(4-((1-丙基氮杂环丁烷-3-基)氧基)苯基)-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚 | ||
| English alias | (1R,3R)-2-(2-Fluoro-2-methylpropyl)-3-methyl-1-(4-((1-propylazetidin-3-yl)oxy)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole | 帕拉司群 | ||
| CAS number | 2092925-89-6 | molecular formula | C28H36FN3O |
| molecular weight | 449.60 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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