CAS number：168425-64-7 molecular formula：C16H15N3O2
Product Introduction A cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 µM). Exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Shown to induce apoptosis and inhibit mTOR-dependent growth in TSC1-/- murine embryo fibroblasts.
| Chinese alias | 化合物401 | 2-吗啉基-4H-嘧啶并[2,1-a]异喹啉-4-酮 | ||
| English alias | HMS3229D15 | 2-(4-MORPHOLINYL)-4H-PYRIMIDO[2,1-A]ISOQUINOLIN-4-ONE | Compound 401 - CAS 168425-64-7 | 4H-Pyrimido[2,1-a]isoquinolin-4-one, 2-(4-morpholinyl)- | TN9PWB4UM5 | AKOS016369524 | AKOS000620372 | AKOS000177882 | 4H-Pyrimido(2,1-a)isoquinolin-4-on | ||
| CAS number | 168425-64-7 | molecular formula | C16H15N3O2 |
| molecular weight | 281.32 g/mol | Exact mass | 10mM in DMSO |
| PSA | 45.100 Ų | logp | 1.200 |
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