compound introduction
Purity >90% SDS-PAGE. Additional sequence information This product is for the mature full length protein. The signal peptide is not included. NP_033971 Function Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. Post-translational N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
