CCNB1, also known as cyclin B1, is a regulatory protein involved in mitosis. This protein complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. Recombinant human CCNB1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Post-translational: Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction (PubMed:16009132).Deubiquitinated by USP22 during G2/M phase (PubMed:27030811). Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.
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Recombinant Human Cyclin B1 Protein
CAS number：unknown molecular formula：
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| Chinese alias | 重组人Cyclin B1蛋白 | 重组人细胞周期蛋白B1 | ||
| English alias | CCNB | CCNB 1 | ccnb1 | CCNB1_HUMAN | Cyclin B1 | G2 mitotic specific cyclin B1 | G2/mitotic-specific cyclin-B1 | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无载体 |
| PSA | - | logp | - |
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