组织蛋白酶G,人中性粒细胞

这种酶会降解胶原蛋白和蛋白多糖，也会导致血管紧张素I或血管紧张素原释放血管紧张素II。它与肺气肿和类风湿性关节炎等结缔组织疾病有关。 This enzyme degrades collagen and proteoglycan and can also cause the release of angiotensin II from angiotensin I or angiotensinogen. It has been implicated in connective tissue diseases such as emphysema and rheumatoid arthritis. Ref: Travis, J. et al. 1978. Biochemistry. 17, 5651. Product Citations: Mittendorf, Elizabeth A., Gheath Alatrash, Na Qiao, Yun Wu, Pariya Sukhumalchandra, Lisa S. St John, Anne V. Philips et al. "Breast cancer cell uptake of the inflammatory mediator neutrophil elastase triggers an anticancer adaptive immune response." Cancer research 72, no. 13 (2012): 3153-3162. Baumann, Mathias, Christine TN Pham, and Charaf Benarafa. "SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G." Blood 121, no. 19 (2013): 3900-3907 van den Berg, Carmen W., et al. "Mechanism of Neutrophil Dysfunction: Neutrophil Serine Proteases Cleave and Inactivate the C5a Receptor." The Journal of Immunology 192.4 (2014): 1787-1795. Towstyka NY, Shiromizu CM, Keitelman I, Sabbione F, et al. Modulation of γδ T cell activation by neutrophil elastase. Immunology. 2017 Sep 9. doi: 10.1111/imm.12835. Ksiazek M, et al. Miropin, a Novel Bacterial Serpin from the Periodontopathogen Tannerella forsythia, Inhibits a Broad Range of Proteases by Using Different Peptide Bonds within the Reactive Center Loop. J Biol Chem. 2015 Jan 2;290(1):658-70. doi: 10.1074/jbc.M114.601716. Epub 2014 Nov 11. Thomas MP, et al. Leukocyte Protease Binding to Nucleic Acids Promotes Nuclear Localization and Cleavage of Nucleic Acid Binding Proteins. J Immunol. 2014 Jun 1;192(11):5390-7. doi: 10.4049/jimmunol.1303296. Epub 2014 Apr 25.

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