Purity ≥95% (SDS-PAGE) Endotoxin level ＜0.1 EU/μg Function Angiopoietin-like 7 (ANGPTL7), also known as Corneal-Derived Transcript 6 (CDT6), is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain . ANGPTL7 shares 89% aa sequence identity with mouse and rat ANGPTL7. It is secreted as a 45 ‑ 50 kDa monomer that forms disulfide-linked homotrimers and tetramers via the coiled coil domain . ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated in glaucoma aqueous humor . Its production is up‑regulated in trabecular meshwork cells by glucocorticoids and TGF-beta and in cartilage by TNF-alpha. Overexpression of ANGPTL7 in trabecular meshwork cells inhibits the production of collagen and proteoglycans . When overexpressed in tumor cells it promotes collagen and proteoglycan deposition but inhibits tumor xenograft progression and tumor angiogenesis . Recently, ANGPTL proteins, including ANGPTL-2, -3, -4, -5 and -7, are identified as growth factors in combination with SCF, Thrombopoietin, IGF-II and FGF acidic that enhance the expansion and engraftment of human and mouse hematopoietic stem cells."
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Recombinant Human Angiopoietin-like 7/ANGPTL7 Protein
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| Chinese alias | 血管生成素样蛋白7(ANGPTL7)重组蛋白 | 重组人 ANGPTL7 蛋白 | ||
| English alias | Angiopoietin like 7 | Angiopoietin like factor | Angiopoietin like factor (CDT6) | Angiopoietin related protein 7 | Angiopoietin-like factor | Angiopoietin-like protein 7 | Angiopoietin-related protein 7 | ANGL7_HUMAN | ANGPTL7 | AngX | CDT6 | Cornea deri | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
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