PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase ( Pf DHODH) inhibitor with an IC 50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria In Vitro Malaria is a global parasitic infectious disease caused by Plasmodium parasites, among which Plasmodium falciparum is the most dangerous one with the highest rates of complications and mortality. PfDHODH-IN-2 shows an overall selectivity for PfDHODH (IC 50 =1.113 µM) over hDHODH (IC 50 >50 µM). PfDHODH-IN-2 demonstrats in vitro potency against the 3D7 and Dd2 strains of P. falciparum with IC 50 values of both >20 µM, respectively in whole cell assays. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 1.113 µM (PfDHODH) IC50: >50 µM ( hDHODH)
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PfDHODH-IN-2
CAS number：425629-94-3 molecular formula：C13H12ClNO3S
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| Chinese alias | 磷酸二氢碘酸脱氢酶 | ||
| English alias | - | ||
| CAS number | 425629-94-3 | molecular formula | C13H12ClNO3S |
| molecular weight | 297.76 g/mol | Exact mass | ≥99% |
| PSA | 84.200 Ų | logp | 3.600 |
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