多肽序列：Cyclo(AS-{d-Pro}-PTWI-{Dab}-{Orn}-{d-Dab}-{Dab}-W-{Dab}-{Dab}) Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic . Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC 50 and MIC 90 values both of 0.12 mg/L. Murepavadin also can target the Appearance:Solid IC50& Target:MIC50: 0.12 mg/L( P. aeruginosa ) MIC90: 0.12 mg/L( P. aeruginosa ) IC50: 5.84 μM (gentamicin) In Vitro:Murepavadin has activity against P. aeruginosa with MIC 50 and MIC 90 values both of 0.12 mg/L. Murepavadin inhibits megalin-mediated uptake of gentamicin in vitro with an IC 50 value of 5.84 μM. MCE has not independently confirmed the accura In Vivo:Murepavadin (s.c.; 0-10mg/kg) is active in pre-clinical animal models including infections with XDR isolates. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Murine models of P. aeruginos Biological Activity:Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic . Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC 50 and MIC 90 values both of 0.12 mg/L. Murepavadin also can target the
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Murepavadin TFA
CAS number：944252-63-5(free base) molecular formula：C73H112N22O16(free base)
overview
compound introduction
Specs
| Chinese alias | 莫瑞伐定 三氟乙酸盐 | 莫替尼 | ||
| English alias | POL7080 TFA | ||
| CAS number | 944252-63-5(free base) | molecular formula | C73H112N22O16(free base) |
| molecular weight | 1553.837(free base) | Exact mass | ≥99% |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
