CAS number：1403764-72-6 molecular formula：C16H17N3O4S
PFI-1 是一种有效的 BET 抑制剂，能够有效抑制 BRD4，IC50 值为 0.22 μM。 PFI-1能阻断BET BRDs与H3、H4乙酰化组蛋白尾巴的相互作用。An epigenetic chemical probe. PFI-1 has been used as a bromodomain inhibitor in breast cancer cell line MCF7 dechorionated zebrafish embryos. It has also been used in human peripheral blood mononuclear cells (PBMCs), to inhibit the release of interleukin-6 in lipopolysaccharide (LPS) challenge assay.
| Chinese alias | - | ||
| English alias | BP-28270 | PENTOXYVERINE CITRATE [JAN] | PFI1 | PFI-1 | SW219427-1 | FT-0696776 | NSC777448 | NSC-777448 | SY347010 | 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzene-1-sulfonamide | 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquina | ||
| CAS number | 1403764-72-6 | molecular formula | C16H17N3O4S |
| molecular weight | 347.39 g/mol | Exact mass | - |
| PSA | 96.100 Ų | logp | 1.200 |
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