CAS number：371935-74-9 molecular formula：C19H16N4O3
PI-103是一种多靶点的PI3K抑制剂，对p110α的抑制效果最好，IC50为2 nM (对p110β/δ/γ抑制效果稍弱)，也抑制mTORC1/2和DNA-PK ，IC50分别为20 nM/83 nM和8 nM。An ATP-competitive DNA-PK, PI 3-kinase, and FRAP inhibitor. PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. An ATP-competitive DNA-PK, PI 3-kinase, and FRAP inhibitor.
| Chinese alias | - | ||
| English alias | GTPL5701 | PI 103 hydrobromide | 3-(4-(4-morpholinyl)pyrido[3?,2?:4,5]furo[3,2-d]pyrimidin-2- yl)phenol | 3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol | AC-31514 | BDBM25045 | NSC 81361 | 3-(6-morpholin-4-yl-8-oxa-3,5,10-triazatricyclo[7.4.0 | ||
| CAS number | 371935-74-9 | molecular formula | C19H16N4O3 |
| molecular weight | 348.36 g/mol | Exact mass | - |
| PSA | 84.500 Ų | logp | 2.700 |
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