CAS number：927880-90-8 molecular formula：C24H16F6N6O
RAF265 (CHIR-265)是一种高度选择性的B-Raf和VEGFR2抑制剂，IC50为3-60 nM，也抑制VEGFR2磷酸化， EC50为30 nM，Phase 2。An orally-bioavailable, selective, potent inhibitor of B-Raf and VEGFR-2. RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM. Phase 2. An orally-bioavailable, selective, potent inhibitor of B-Raf and VEGFR-2.
| Chinese alias | - | ||
| English alias | CHIR265 | CHIR-265 | FT-0746327 | HMS3672I21 | NCGC00015003-02 | 1-methyl-5-[2-(5-trifluoromethyl-1H-imidazol-2-yl)pyridin-4-yloxy]-N-(4-trifluoromethylphenyl)-1H-benzo[d]imidazol-2-amine | NCGC00250407-01 | NSC754357 | NSC-754357 | SB16578 | 1-Methyl-5-( | ||
| CAS number | 927880-90-8 | molecular formula | C24H16F6N6O |
| molecular weight | 518.43 g/mol | Exact mass | - |
| PSA | 80.700 Ų | logp | 5.4 |
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