CAS number：213261-59-7 molecular formula：C14H12O3S2
RITA (NSC 652287)诱导DNA-蛋白质和DNA-DNA交联，检测不到DNA单链断裂，通过靶向作用于p53，也抑制MDM2-p53相互作用。A trycyclic thiophene derivative that binds MDM2, activates p53 and induces apoptosis. RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53. A trycyclic thiophene derivative that binds MDM2, activates p53 and induces apoptosis.
| Chinese alias | 5,5'-(2,5-呋喃二基)二-2-噻吩甲醇 | ||
| English alias | BCP06744 | J-504944 | FT-0703160 | HMS3269E07 | [5-[5-[5-(hydroxymethyl)-2-thiophenyl]-2-furanyl]-2-thiophenyl]methanol | AKOS024457101 | EX-A138 | Thiophene-2-methanol,5'-(2,5-furandiyl)bis- | NCIChal_000017 | BRD-K00317371-001-01-2 | NCI60_018346 | HMS3 | ||
| CAS number | 213261-59-7 | molecular formula | C14H12O3S2 |
| molecular weight | 292.37 g/mol | Exact mass | ≥98% |
| PSA | 110.000 Ų | logp | 2.000 |
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