CAS number：1062169-56-5 molecular formula：C24H29N7O5
WYE-354是ATP竞争性mTOR抑制剂，IC50为5 nM，能阻断mTORC1/P-S6K(T389)和mTORC2/P-AKT(S473)，比对PI3Kα和PI3Kγ的抑制性强100倍和500倍。A potent, specific, and ATP-competitive inhibitor to mTOR with IC50 of 5 nM WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) not P-AKT(T308), selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold). A potent, specific, and ATP-competitive inhibitor to mTOR with IC50 of 5 nM
| Chinese alias | - | ||
| English alias | 1062169-56-5 | J-514253 | WYE354 | WYE-354 | HMS3654N09 | FT-0675866 | S1266 | AS-55957 | MFCD00008199 | NCGC00242484-09 | AKOS027314120 | EX-A5295 | W-108761 | CHEBI:94742 | mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5 | NCGC00258510-01 | SCHEMBL | ||
| CAS number | 1062169-56-5 | molecular formula | C24H29N7O5 |
| molecular weight | 495.54 g/mol | Exact mass | - |
| PSA | 124.000 Ų | logp | 1.900 |
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