compound introduction
SB203580 HCl是p38-MAPKs特异性抑制剂，其IC50值为0.6 μM。 SB203580是p38-MAPKα和p38-MAPKβ的抑制剂。在新生肌细胞中，SB203580阻止p38-MAPK激活MAPKAPK2，其IC50值为70 nM。在KB细胞中，SB203580还通过IL-1、渗透压力或亚砷酸盐显著抑制MAPKAPK2活化。在KB细胞中，SB203580也抑制IL-1、化学物质或渗透压力诱导的HSP27磷酸化，其IC50值
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SB 203580 hydrochloride
CAS number：869185-85-3 molecular formula：C21H16FN3OS.HCl
overview
Specs
| Chinese alias | 4-[4-(4-氟苯基)-2-[4-(甲基亚磺酰基)苯基]-1H-咪唑-5-基]吡啶盐酸盐 | ||
| English alias | 4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridinehydrochloride | SB 203580 | p38 MAP Kinase Inhibitor XVI, Hydrochloride | 4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine hydrochloride | ||
| CAS number | 869185-85-3 | molecular formula | C21H16FN3OS.HCl |
| molecular weight | 413.9 g/mol | Exact mass | - |
| PSA | 77.900 Ų | logp | - |
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physicochemical properties
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