compound introduction
THZ-P1-2 是一种首创的，选择性的PI5P4K抑制剂，对 PI5P4Kα 的IC50为 190 nM。THZ-P1-2 共价靶向 PI5P4Kα/β/γ 中无序环上的半胱氨酸。THZ-P1-2 引起自噬破坏，上调 TFEB 信号传导。THZ-P1-2 在白血病细胞系中显示抗癌活性。
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CID 134451950
CAS number：2058075-45-7 molecular formula：C31H29N7O2
overview
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2058075-45-7 | molecular formula | C31H29N7O2 |
| molecular weight | 531.600 g/mol | Exact mass | ≥99% |
| PSA | 115.000 Ų | logp | 4.200 |
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