Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining Description: Human B7 homolog 3 (B7-H3) is a member of the B7 family of immune proteins that provide signals for the regulation of immune responses. Other family members include B7-1, B7-2, B7-H1/PD-L1, B7-H2, and PD-L2. B7 family proteins are type I transmembrane immunoglobulin (Ig) superfamily members that contain extracellular Ig V‑like and Ig C‑like domains with a short cytoplasmic tail. Among the family members there is about 20 - 40% amino acid (aa) sequence identity. B7-H3 was initially reported to be a 316 aa type I transmembrane precursor protein that contained a signal sequence, an extracellular region with one V‑type and one C‑type Ig domain, a transmembrane segment and a short cytoplasmic tail. Subsequent studies have identified a second 110 kDa form whose precursor is 534 aa in length. Termed 4IgB7-H3 or B7-H3b, this molecule has two additional Ig-like domains (one V‑type and one C‑type) and shows a ubiquituous expression pattern. It would appear that the human 4Ig form is the principal, if not the only form of B7-H3. Its precursor contains a 26 aa signal sequence, a 435 aa extracellular region, a 31 aa transmembrane domain, and a 42 aa cytoplasmic tail. The four Ig-like domains alternate between V‑type and C‑type, and apparently are the consequence of a V‑C type tandem duplication. B7-H3b is expressed on dendritic cells as well as activated T, B and NK cells. The mouse gene differs from that of human in that it cannot code for four Ig-like domains; only a V‑type:C‑type pair. Human B7-H3b binding to an undefined receptor has shown to be inhibitory to NK cell illing and cytokine release. It also seems to be required for late stage osteoblast differentiation.
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Recombinant Human B7-H3(4Ig)/B7-H3b Protein
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| Chinese alias | 重组人B7-H3 (4Ig)/B7-H3b蛋白 | 重组人 B7-H3(4Ig)/B7-H3b 蛋白 | ||
| English alias | 4Ig-B7-H3 | B7 homolog 3 | B7-H3 | Costimulatory molecule | 4Ig B7 H3 | 4Ig-B7-H3 | B7H34Ig-B7-H3 | B7-H3B7 homolog 3 | AU016588 | B7 H3 | B7 homolog 3 | B7-H3 | B7H3 | B7RP-2 | CD_antigen=CD276 | CD276 | CD276 antigen | CD276 molecule | CD276_HUMAN | Cos | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
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