compound introduction
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.
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dBET1
CAS number：1799711-21-9 molecular formula：C38H37ClN8O7S
overview
Specs
| Chinese alias | - | ||
| English alias | (6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide | SG5-025 | ||
| CAS number | 1799711-21-9 | molecular formula | C38H37ClN8O7S |
| molecular weight | 785.27 g/mol | Exact mass | 10mM in DMSO |
| PSA | 222.000 Ų | logp | 3.200 |
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