CAY10502是一种有效的钙依赖型胞质PLA2(cPLA2α)抑制剂,对从人血小板中纯化的酶的IC50值为4.3 nM。抑制花生四烯酸从A23187刺激或TPA刺激的人血小板中的动员,其IC50值分别为570和0.9 nM。 CAY10502 is a potent Calcium-dependent cytosolic PLA2 (cPLA2α) inhibitor with an IC50 value of 4.3 nM for the purified enzyme from human platelets. Inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively.
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CAY10502
CAS number:888320-29-4 molecular formula:C30H37NO7
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| Chinese alias | - | ||
| English alias | BDBM50185354 | compound 57 [PMID: 16610804] | HMS3650G20 | HY-116301 | 1-(3-(4-(Decyloxy)phenoxy)-2-oxopropyl)-3-(methoxycarbonyl)-1H-indole-5-carboxylic acid | 1-[3-(4-decoxyphenoxy)-2-oxopropyl]-3-methoxycarbonylindole-5-carboxylic acid | MS-29698 | AKO | ||
| CAS number | 888320-29-4 | molecular formula | C30H37NO7 |
| molecular weight | 523.62 g/mol | Exact mass | - |
| PSA | 104.000 Ų | logp | 7.400 |
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