CDC25磷酸酶抑制剂I，BN82002是一种细胞可渗透的邻羟基苄氨基化合物，据报道它具有抗肿瘤特性。它已被证明可作为 CDC25 磷酸酶家族的有效、选择性和不可逆抑制剂（25A、25B2、25B3、25C 和 25C-cat 的 IC|50|= 2.4、3.9、6.3、5.4 和 4.6 μM，分别）。据报道，对 CDC25 磷酸酶的选择性比 CD45 酪氨酸磷酸酶高约 20 倍。还显示延迟细胞周期进程|体外|(IC|50|= ~7.2-32.6 μM)，并减少异种移植人胰腺细胞 MIA PaCa-2 (15 mg/kg, i.p. route) 的无胸腺小鼠的肿瘤生长. CDC25 Phosphatase Inhibitor I, BN82002, is a cell-permeable ortho-hydroxybenzylamino compound that has been reported to display antitumor properties. It has been shown to act as a potent, selective and irreversible inhibitor of the CDC25 phosphatase family (IC|50|= 2.4, 3.9, 6.3, 5.4, and 4.6 μM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). Reported to display a ~20-fold greater selectivity for CDC25 phosphatases over CD45 tyrosine phosphatase. Also shown to delay cell cycle progression|in vitro|(IC|50|= ~7.2-32.6 μM), and reduces tumor growth in athymic mice xenografted with the human pancreatic cells MIA PaCa-2 (15 mg/kg, i.p. route).
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CDC25 Phosphatase Inhibitor I, BN82002
CAS number：396073-89-5 molecular formula：C19H25N3O4
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| Chinese alias | - | ||
| English alias | BCP29552 | GOKYHQGRIIXMNE-UHFFFAOYSA-N | AKOS037515620 | BN82002 | BN-82002 | HSCI1_000079 | HY-112776 | 4-(dimethylamino)-2-methoxy-6-[[methyl-[2-(4-nitrophenyl)ethyl]amino]methyl]phenol | NCGC00165741-01 | BN82002 HYDROCHLORIDE SALT | D93454 | Q27253727 | ||
| CAS number | 396073-89-5 | molecular formula | C19H25N3O4 |
| molecular weight | 359.4 g/mol | Exact mass | ≥97% |
| PSA | 81.800 Ų | logp | 3.300 |
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