compound introduction
组织蛋白酶L抑制剂（Z-FY-CHO）是组织蛋白酶L的一种有效且选择性的抑制剂。在未分馏大鼠骨细胞的凹坑形成试验中，1.5 nM Z-FY-CHO显着抑制了甲状旁腺激素刺激的破骨细胞骨吸收。在卵巢切除的小鼠中，它以2.5-10 mg / kg /天ip的剂量抑制了四周的骨量减轻。 Cathepsin L inhibitor (Z-FY-CHO) is a potent and selective inhibitor of Cathepsin L. In the pit formation assay with unfractionated rat bone cells, 1.5 nM of Z-FY-CHO markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption. In ovariectomized mice, it suppressed at 2.5-10 mg/kg/day ip for four weeks bone weight loss dose-dependently.
