compound introduction
γ-CEHC是饮食性γ-生育酚的β氧化代谢产物，可作为利尿激素。它最初是从尿毒症患者的尿液中鉴定和纯化的，但此后在充血性心力衰竭患者和对照患者的尿液中均已发现。γ-CEHC还具有抗炎作用，可减少大鼠模型中的8-异前列腺素和炎性类花生酸的合成。从天然饮食中获得的主要生育酚是γ-生育酚，而α-生育酚是通常从合成补品中获得的维生素E的形式。 γ-CEHC is a β-oxidized metabolite of dietary γ-tocopherol that functions as a natriure hormone. It was initially characterized and purified from the urine of uremic patients, but it has since been found in urine from both those with congestive heart failure and control patients. γ-CEHC is also anti-inflammatory, reducing 8-isoprostane and inflammatory eicosanoid synthesis in rat models. The major tocopherol obtained from natural dietary sources is γ-tocopherol, whereas α-tocopherol is the form of Vitamin E typically obtained from synthetic supplements.
