compound introduction
1,4 DPCA是选择性和有效的脯氨酰4-羟基化（P4H）|抑制剂。已经显示出抑制α-脯氨酰基4-羟化酶，一种氧敏感酶，其靶向促血管生成因子HIF-1α，以在特定脯氨酸残基羟化时被破坏。1,4-DPCA还显示出抑制天冬酰胺基羟化酶因子抑制HIF（FIH），可用于控制病理性纤维化中过多的胶原蛋白沉积。 1,4 DPCA is a selective and potent inhibitor of prolyl 4-hydroxylation (P4H)|in vitro|. It has been shown to Inhibit α-prolyl 4-hydroxylase, an oxygen-sensing enzyme that targets the pro-angiogenic factor HIF-1α for destruction upon hydroxylation of a specific proline residue. 1,4-DPCA has also been shown to inhibit asparaginyl-hydroxylase factor inhibiting HIF (FIH) and to be useful for controlling excess collagen deposition in pathological fibrosis.
