compound introduction
与花生四烯酸孵育后，在人的血小板和神经组织中合成12-OxoETE。各种组织的微粒体级分会将12-oxoETE降低为12（S）-HETE或12（S）-和12（R）-HETE的混合物。12-OxoETE通过白三烯B4受体或共同的激活序列诱导剂量依赖性的细胞质游离钙快速增加。 12-OxoETE is synthesized by human platelets and|Aplysia|nervous tissue after incubation with arachidonic acid. Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-HETE. 12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via an Leukotriene B4 receptor or a common activation sequence.
