compound introduction
亚油酸的脂氧合酶代谢产物。13（S）-HODE调节人多形核白细胞中的血小板活化因子，白三烯B4和甲酰-Met-Leu-Phe诱导的钙内流。13（S）-HODE发挥其抑制作用的机制仍不清楚。使用生物素化的15（S）-HETE作为探针来检测特异性结合15（S）-HETE的结合蛋白和/或受体，为13（S）-HODE-生物素的类似用途提供了基础。 The lipoxygenase metabolite of linoleic acid. 13(S)-HODE modulates the platelet-activating factor, leukotriene B4, and formyl-Met-Leu-Phe-induced calcium influx in human polymorphonuclear leukocytes. The mechanism that 13(S)-HODE uses to elicit its inhibitory effect is still unclear. The use of biotinylated 15(S)-HETE as a probe for detecting binding proteins and/or receptors that specifically bind 15(S)-HETE provides a basis for similar use of 13(S)-HODE-biotin.
