compound introduction
15（S）-HETE-生物素是由15-LO（15-脂氧合酶）途径产生的主要花生四烯酸代谢产物，其特征是有效的5-LO抑制剂。15（S）-HETE充当白三烯抑制剂的机制尚不清楚。在对P-18肥大/嗜碱性粒细胞的研究中，表明特定的15-HETE受体似乎不参与酯化，而参与信号转导。15（S）-HETE-生物素可用于检测15（S）-HETE结合蛋白和/或受体。 15(S)-HETE-biotin is a major arachidonic acid metabolite produced by the 15-LO (15-lipoxygenase) pathway and is characterized as a potent inhibitor of 5-LO. The mechanism by which 15(S)-HETE acts as a leukotriene inhibitor is not clear. In studies with P-18 mast/basophil cells, it was shown that specific 15-HETE receptors, rather than esterification, appeared to be involved in signal transduction. 15(S)-HETE-biotin can be used to detect 15(S)-HETE binding proteins and/or receptors. 15(S)-HETE-biotinis an inhibitor of 5-LO (5-lipoxygenase)
