H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) is an antihypertensive peptide. H-Tyr-Tyr-OH inhibits angiotensin I-converting enzyme ( ACE ) with an IC 50 value of 0.028 mg/mL. H-Tyr-Tyr-OH can be used for the research of high blood pressure In Vitro H-Tyr-Tyr-OH shows inhibitory effect against ACE with an IC 50 value of 0.028 mg/mL. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo H-Tyr-Tyr-OH (12.5 mg/kg; intraarterial injection once) effects systolic blood pressure in vivo . H-Tyr-Tyr-OH (0-100 mg/kg; i.p. once) effects blood pressure of spontaneously hypertensive rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Anesthetized male SpragueDawley rats Dosage: 12.5 mg/kg Administration: Intraarterial injection; 12.5 mg/kg once Result: Significantly elevated systolic blood pressure, with a peak increase of 5 min after administration. Animal Model: Spontaneously hypertensive rats Dosage: 0, 50 and 100 mg/kg Administration: Intraperitoneal injection; once Result: Significantly reduced blood pressure of spontaneously hypertensive rats, even at a dose of 50 mg/kg. Form:Solid IC50& Target:IC50: 0.028 mg/mL (ACE)
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
H-Tyr-Tyr-OH
CAS number：1050-28-8 molecular formula：C18H20N2O5
overview
compound introduction
Specs
| Chinese alias | H-酪氨酸-酪氨酸-OH | ||
| English alias | Q27130548 | Tyrosyltyrosine | Tyrosyl-Tyrosine | Peptide tyrosine-tyrosine | MS-25280 | H-TYR-TYR-OH | AKOS030525649 | YY | di-L-tyrosine | Dipiroxim | BDBM50081840 | L-Tyr-L-Tyr | (S)-2-((S)-2-Amino-3-(4-hydroxyphenyl)Propanamido)-3-(4-hydroxyphenyl)Prop | ||
| CAS number | 1050-28-8 | molecular formula | C18H20N2O5 |
| molecular weight | 344.36 g/mol | Exact mass | - |
| PSA | 133.000 Ų | logp | -1.900 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
